Cytochrome P450 2B6 6 distribution among Burkinabè population

Mutations affect the genes that encode certain cytochromes P450 (CYP450) isoenzymes are responsible for metabolism of drugs. The aim this study was to determine frequency CYP2B6 (516G>T) SNP in Burkinabè population. Genomic DNA extraction from blood performed by GenJET® according manufacturer’s instructions. Genotyping cytochrome variant alleles using predesigned primers. amplification carried out PCR while differentiation between after digestion with restriction enzymes electrophoresis. c.516G>T successfully analyzed 92,38% (291/315) participants. Among investigated individuals, distribution major allele CYP2B6*G 56% and minor CYP2B6*T 44%. results obtained showed a prevalence G 44% T allele. This distributed as 31% GG genotype (reduced dosage required), 51% GT (normal range), 18% TT (high drug toxicity). presence rapid poor metabolizer phenotypes studied sample shows need additional studies better assess their impact on Burkinabe people.